Methanol → HCID 136398813, compound

HRID 1863433Notes

Reaction equation

HRID 1863433 reaction equation
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH:17]=O.CO.[C:21]([O:25][CH3:26])(=[O:24])[NH:22][NH2:23]>C(O)(=O)C>[CH3:26][O:25][C:21](=[O:24])[NH:22][N:23]=[CH:17][C:3]1[N:4]=[C:5]([C:7]2[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=2)[NH:6][C:2]=1[CH3:1]

Participants

5

Reactant 3

HCID 887MethanolHCID 80519Methyl carbazateHCID 20391365HCID 20391365, compound

Product 1

HCID 136398813HCID 136398813, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 5-methyl-2-(α,α,α-trifluoro-m-tolyl)imidazole-4-carboxaldehyde (20.0 g, 0.0787 mole), methanol (500 ml), methyl carbazate (7.8 g) and glacial acetic acid (0.5 ml) is refluxed overnight. The solution is then concentrated to afford 23.14 g of title product. A sample is recrystallized from methanol-acetone, m.p. 251°-251.5° C.

Workup

  1. temperatureis refluxed overnight
  2. concentrationThe solution is then concentrated

Sources & evidence

ORD record
ord-8d21a9c1d9af4509b0e178cfa6926d6a
Source dataset
uspto-grants-1979_09
Patent number
US04168964

Reaction notes

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