1H-1,2,4-Triazole, 1-acetyl-3-(p-chlorophenyl)-5-methyl- → 3-(4-Chlorophenyl)-5-methyl-1H-1,2,4-triazole

HRID 1863471Notes

Reaction equation

HRID 1863471 reaction equation
C([N:4]1[C:8]([CH3:9])=[N:7][C:6]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[N:5]1)(=O)C>O>[Cl:16][C:13]1[CH:12]=[CH:11][C:10]([C:6]2[N:7]=[C:8]([CH3:9])[NH:4][N:5]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 1

HCID 30504871H-1,2,4-Triazole, 1-acetyl-3-(p-chlorophenyl)-5-methyl-

Product 1

HCID 124680223-(4-Chlorophenyl)-5-methyl-1H-1,2,4-triazoleYield 105.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

27 g (114 mM) 1-Acetyl-3-(4-chlorophenyl)-5-methyl-1H-1,2,4-triazole is refluxed in 800 ml of water for 9 hours and stirred overnight at room temperature. The product is filtered out, washed with water, and dried at 90° under vacuum overnight to give 23.4 g of the title compound, m.p. 173°-175°.

Workup

  1. filtrationThe product is filtered out
  2. washwashed with water
  3. customdried at 90° under vacuum overnight

Sources & evidence

ORD record
ord-ea90009cd2be4930b7e0cb19c898ba60
Source dataset
uspto-grants-1979_09
Patent number
US04169148

Reaction notes

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