HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-1,2,4-Triazole, 1-acetyl-3-(p-chlorophenyl)-5-methyl- → 3-(4-Chlorophenyl)-5-methyl-1H-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-1,2,4-Triazole, 1-acetyl-3-(p-chlorophenyl)-5-methyl- | HCID 3050487 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(4-Chlorophenyl)-5-methyl-1H-1,2,4-triazole | HCID 12468022 | 105.5% |
Reaction Steps
27 g (114 mM) 1-Acetyl-3-(4-chlorophenyl)-5-methyl-1H-1,2,4-triazole is refluxed in 800 ml of water for 9 hours and stirred overnight at room temperature. The product is filtered out, washed with water, and dried at 90° under vacuum overnight to give 23.4 g of the title compound, m.p. 173°-175°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04169148 |
| Source dataset | uspto-grants-1979_09 |
| ORD ID | ord-ea90009cd2be4930b7e0cb19c898ba60 |
| Source note | uspto-grants-1979_09 |