反应详情

A solution of n-butyl lithium in n-hexane (1.6 N, 1.6 ml) was added to 10,11-dihydro-5H-dibenzo[a,d]cycloheptene (390 mg) in anhydrous tetrahydrofuran at room temperature, and the resulting mixture was stirred under reflux for 40 minutes. A solution of 2-chloromethyl-4-isopropylmorpholine (362 mg) in benzene was added thereto while stirring under heating, and the resulting mixture was stirred under reflux for 4 hours, followed by addition of excess water. The reaction mixture was extracted with ethyl acetate. The ethyl acetate extract was dried, evaporated and chromatographed to afford 5-(4-isopropylmorpholin-2-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cycloheptene as oily material. M.P., 219°-221° C. (hydrochloride).

1. temperatureunder reflux for 40 minutes
2. stirringwhile stirring
3. temperatureunder heating
4. stirringthe resulting mixture was stirred
5. temperatureunder reflux for 4 hours
6. extractionThe reaction mixture was extracted with ethyl acetate
7. extractionThe ethyl acetate extract
8. customwas dried
9. customevaporated
10. customchromatographed