Hydrochloric Acid → HCID 68523413, compound

HRID 1863925Notes

Reaction equation

HRID 1863925 reaction equation
[O:1]=[C:2]1[C:7]2[N:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[N:10]=[CH:11][C:6]=2[CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.Cl>O1CCOCC1>[F:15][C:12]([F:13])([F:14])[C:9]1[N:10]=[CH:11][C:6]2[CH2:5][CH2:4][NH:3][C:2](=[O:1])[C:7]=2[N:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68524098HCID 68524098, compound

Product 1

HCID 68523413HCID 68523413, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Approximately 485 mg (1.53 mmol) of tert-butyl 8-oxo-2-(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate was treated with 10 mL of 4M HCl in anhydrous dioxane, and the solution was stirred at room temperature for 0.5 h, then concentrated to dryness. The residue was washed with diethyl ether and dried to give the title compound as a white solid. LC-MS 218 (M+1).

Workup

  1. concentrationconcentrated to dryness
  2. washThe residue was washed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-03cd092c21e3479c8be45433c6e5e74e
Source dataset
uspto-grants-2009_12
Patent number
US07625888B2

Reaction notes

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