Hydrazine → HCID 57973798, compound

HRID 1863943Notes

Reaction equation

HRID 1863943 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1.[NH2:15][NH2:16]>C(O)C>[NH:15]([C:2]1[C:7]2[N:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1)[NH2:16]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 573550614-Chloro-2-(trifluoromethyl)-1H-imidazo[4,5-c]pyridine

Product 1

HCID 57973798HCID 57973798, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 132 mg (0.6 mmol) of 4-chloro-2-(trifluoromethyl)-1H-imidazo[4,5-c]pyridine, 0.0787 mL (2.4 mmol) of anhydrous hydrazine, and 3 mL of ethanol was stirred at reflux for 2 days. The cooled, filtered solution was concentrated, and the residue was partitioned between ethyl acetate and water. The organic phase was dried over sodium sulfate, filtered and concentrated to yield the title compound. LC-MS 218 (M+1).

Workup

  1. temperatureat reflux for 2 days
  2. filtrationThe cooled, filtered solution
  3. concentrationwas concentrated
  4. customthe residue was partitioned between ethyl acetate and water
  5. dry with materialThe organic phase was dried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-4b221de47417491e97996dd4f66fc15d
Source dataset
uspto-grants-2009_12
Patent number
US07625888B2

Reaction notes

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