Methanol → HCID 91124768, compound

HRID 1863950Notes

Reaction equation

HRID 1863950 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:9][C:10]([NH:12][NH2:13])=[O:11])([CH3:4])([CH3:3])[CH3:2].CO[C:27]1[C:32]2[N:33]=[C:34]([C:37]([F:40])([F:39])[F:38])[N:35]=[CH:36][C:31]=2[CH2:30][CH2:29][N:28]=1.CO>C(OCC)C>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:9][C:10](=[O:11])[NH:12][NH:13][C:27]1[C:32]2[N:33]=[C:34]([C:37]([F:39])([F:40])[F:38])[N:35]=[CH:36][C:31]=2[CH2:30][CH2:29][N:28]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 887MethanolHCID 57973796HCID 57973796, compound2×HCID 57973805HCID 57973805, compound2×

Product 1

HCID 91124768HCID 91124768, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 150 mg (0.433 mmol) of tert-butyl[(1R)-3-hydrazino-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate (Intermediate 4), 100 mg (0.433 mmol) of 8-methoxy-2-(trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidine (Intermediate 5) and 4 mL of anhydrous methanol was stirred at room temperature for 5.5 h and then diluted with diethyl ether. The solid was collected on a filter and dried to give the title compound. LC-MS 547 (M+1).

Workup

  1. customThe solid was collected on
  2. filtrationa filter
  3. customdried

Sources & evidence

ORD record
ord-173cd2a85f8a4ece84eac11d10bd89d6
Source dataset
uspto-grants-2009_12
Patent number
US07625888B2

Reaction notes

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