Tert-butyl[(1r)-1-(2,5-difluorobenzyl)-3-hydrazino-3-oxopropyl]carbamate → Tert-butyl[(1r)-2-(10-chloro-5,6-dihydro[1,2,4]triazolo[4,3-d][1,4]benzoxazepin-3-yl)-1-(2,5-difluorobenzyl)ethyl]carbamate

HRID 1863961Notes

Reaction equation

HRID 1863961 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[F:22])[CH2:9][C:10]([NH:12][NH2:13])=O)([CH3:4])([CH3:3])[CH3:2].[Cl:24][C:25]1[CH:26]=[CH:27][C:28]2[O:34][CH2:33][CH2:32][N:31]=[C:30](OC)[C:29]=2[CH:37]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[F:22])[CH2:9][C:10]1[N:31]2[CH2:32][CH2:33][O:34][C:28]3[CH:27]=[CH:26][C:25]([Cl:24])=[CH:37][C:29]=3[C:30]2=[N:13][N:12]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 57973777Tert-butyl[(1r)-1-(2,5-difluorobenzyl)-3-hydrazino-3-oxopropyl]carbamate2×HCID 579737927-Chloro-2,3-dihydro-5-methoxybenzo[F][1,4]oxazepine2×

Product 1

HCID 91178718Tert-butyl[(1r)-2-(10-chloro-5,6-dihydro[1,2,4]triazolo[4,3-d][1,4]benzoxazepin-3-yl)-1-(2,5-difluorobenzyl)ethyl]carbamate

Procedure

By the procedure of Example 5, Step A, the title compound was prepared from tert-butyl[(1R)-1-(2,5-difluorobenzyl)-3-hydrazino-3-oxopropyl]carbamate (Intermediate 2) and 7-chloro-5-methoxy2,3-dihydro-1,4-benzoxazepine (Intermediate 15). LC-MS 491 (M+1).

Sources & evidence

ORD record
ord-9f3ac25d76af4d1b8e6ab3ee6390e51b
Source dataset
uspto-grants-2009_12
Patent number
US07625888B2

Reaction notes

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