p-Bromobenzyl chloride → 1-Bromo-4-{[(2S)-3-methoxy-2-methylpropoxy]methyl}benzene

HRID 1863974Notes

Reaction equation

HRID 1863974 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][CH:3]=1.[CH3:10][O:11][CH2:12][C@H:13]([CH3:16])[CH2:14][OH:15]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:15][CH2:14][C@@H:13]([CH3:16])[CH2:12][O:11][CH3:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 68528p-Bromobenzyl chlorideHCID 56924404(2R)-3-Methoxy-2-methylpropan-1-ol

Product 1

HCID 454896741-Bromo-4-{[(2S)-3-methoxy-2-methylpropoxy]methyl}benzene

Procedure

According to general method E, 1-bromo-4-chloromethyl-benzene [589-17-3] and (R)-3-methoxy-2-methyl-propan-1-ol are used to afford the title compound as a yellow oil. Rf=0.44 (EtOAc-heptane 1:6); Rt=5.29 (gradient I).

Sources & evidence

ORD record
ord-8cf95cef1454405c80effb01aa4b2b4e
Source dataset
uspto-grants-2009_12
Patent number
US07625893B2

Reaction notes

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