2-Chloroethanol → 1-chloro-3-(2-chloroethoxy)propan-2-ol

Temperature

45 °C

step 1—To a solution of R-(−)-epichlorohydrin (7 mL, 89.27 mmol) and DCE (280 mL) was added 2-chloroethanol (6.3 mL, 93.74 mmol) followed by a solution of BF3 Et2O (1.1 mL, 8.927 mmol) and DCE (20 mL). The pale yellow solution was stirred at 45° C. for 2 h. The reaction mixture was allowed to cool to RT, evaporated and dried in vacuo overnight (yield>95%) to afford 1-chloro-3-(2-chloro-ethoxy)-propan-2-ol.

1. temperatureto cool to RT
2. customevaporated
3. customdried in vacuo overnight (yield>95%)

ORD record

ord-14118c3484ba41fe836c68be47e40009

Source dataset

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07625891B2