2,2-Dimethylethenylboronic acid → HCID 131727806, compound

HRID 1864025Notes

Reaction equation

HRID 1864025 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:18]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)[N:11]3[C:12](=[O:17])[C:13](I)=[CH:14][CH:15]=[C:10]3[N:9]2[S:26]([C:29]2[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=2)[C:32]#[N:33])(=[O:28])=[O:27])=[CH:4][CH:3]=1.[CH3:37][C:38]([CH3:43])=[CH:39]B(O)O>CO.C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:18]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)[N:11]3[C:12](=[O:17])[C:13]([CH:37]=[C:38]([CH3:43])[CH3:39])=[CH:14][CH:15]=[C:10]3[N:9]2[S:26]([C:29]2[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=2)[C:32]#[N:33])(=[O:28])=[O:27])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 27632992,2-Dimethylethenylboronic acidHCID 131727795HCID 131727795, compound

Product 1

HCID 131727806HCID 131727806, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The titled compound was prepared according to general method D by reaction of rac-3-[cis-2,3-bis-(4-chloro-phenyl)-5-oxo-2,3-dihydro-6-iodo-5H-imidazo[1,2-a]pyridine-1-sulfonyl]-benzonitrile with 2,2-dimethylethenylboronic acid. The compound was isolated by FCC (2.5% MeOH/DCM). The expected product was characterized by 1H NMR

Workup

  1. customThe titled compound was prepared

Sources & evidence

ORD record
ord-af7cab8b2be848bba0c76e5b9e70cfd6
Source dataset
uspto-grants-2009_12
Patent number
US07625895B2

Reaction notes

Loading…