Morpholine → HCID 131727807, compound

HRID 1864026Notes

Reaction equation

HRID 1864026 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:19]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)[N:11]3[C:12](=[O:18])[C:13]([CH:16]=O)=[CH:14][CH:15]=[C:10]3[N:9]2[S:27]([C:30]2[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=2)[C:33]#[N:34])(=[O:29])=[O:28])=[CH:4][CH:3]=1.[NH:38]1[CH2:43][CH2:42][O:41][CH2:40][CH2:39]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[C@@H:19]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)[N:11]3[C:12](=[O:18])[C:13]([CH2:16][N:38]4[CH2:43][CH2:42][O:41][CH2:40][CH2:39]4)=[CH:14][CH:15]=[C:10]3[N:9]2[S:27]([C:30]2[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=2)[C:33]#[N:34])(=[O:28])=[O:29])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 131727808HCID 131727808, compound

Product 1

HCID 131727807HCID 131727807, compound

Procedure

rac-3-[cis-2,3-Bis-(4-chloro-phenyl)-6-morpholin-4-ylmethyl-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-sulfonyl]-benzonitrile was prepared according to general method E by reaction of rac-3-[cis-2,3-bis-(4-chloro-phenyl)-6-formyl-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-sulfonyl]-benzonitrile with Morpholine. The compound was isolated by preparative HPLC. The expected product was characterized by LC/MS (M+H) where the mass was observed as 621.06; the expected mass is 620. LC/MS indicated a purity of 100% as measured by UV 214 nM.

Workup

  1. customThe compound was isolated by preparative HPLC

Sources & evidence

ORD record
ord-4dc3f166925045c2b9bef84e8e92c6f4
Source dataset
uspto-grants-2009_12
Patent number
US07625895B2

Reaction notes

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