Ethylamine → HCID 69057020, compound

HRID 1864204Notes

Reaction equation

HRID 1864204 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[C:7]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)=[C:18]([Cl:30])[CH:17]=1)=[N:8][CH:9]=[N:10]2.[CH2:31]([NH2:33])[CH3:32]>>[Cl:30][C:18]1[CH:17]=[C:16]([NH:15][C:7]2[C:6]3[C:11](=[CH:12][CH:13]=[CH:14][C:5]=3[O:4][CH2:3][CH2:2][NH:33][CH2:31][CH3:32])[N:10]=[CH:9][N:8]=2)[CH:21]=[CH:20][C:19]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1

Participants

3

Reactant 2

HCID 6341EthylamineHCID 57501935HCID 57501935, compound

Product 1

HCID 69057020HCID 69057020, compound

Procedure

5-(2-Chloroethoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine (0.400 g) and ethylamine (1.2 g) were heated at 50° C. overnight and then the solution purified by chromatography using DCM to 10% 7N ammonia in methanol in DCM to give N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(ethylamino)ethoxy]quinazolin-4-amine; Mass spectrum MH+ 450.

Workup

  1. customthe solution purified by chromatography

Sources & evidence

ORD record
ord-121a3dfff7ff4caba1911f6a2935b209
Source dataset
uspto-grants-2009_12
Patent number
US07625908B2

Reaction notes

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