反应详情

The procedure described in Example 3 (preparation of starting materials) was repeated using methoxyacetic acid and 2-chloro-4-[(5-{[(2S)-2-(methylamino)propyl]oxy}quinazolin-4-yl)amino]phenol (obtained as described in Example 56, preparation of starting materials) to give N-[(1S)-2-({4-[(3-chloro-4-hydroxyphenyl)amino]quinazolin-5-yl}oxy)-1-methylethyl]-2-methoxy-N-methylacetamide in 49% yield; Mass spectrum MH+ 429.2.

1. customThe procedure described in Example 3 (preparation of starting materials)