Methoxyacetic Acid → HCID 69063687, compound

HRID 1864263Notes

Reaction equation

[CH3:1][O:2][CH2:3][C:4]([OH:6])=O.[Cl:7][C:8]1[CH:13]=[C:12]([NH:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][C:23]=3[O:25][CH2:26][C@@H:27]([NH:29][CH3:30])[CH3:28])[N:18]=[CH:17][N:16]=2)[CH:11]=[CH:10][C:9]=1[OH:31]>>[Cl:7][C:8]1[CH:13]=[C:12]([NH:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][C:23]=3[O:25][CH2:26][C@@H:27]([N:29]([CH3:30])[C:4](=[O:6])[CH2:3][O:2][CH3:1])[CH3:28])[N:18]=[CH:17][N:16]=2)[CH:11]=[CH:10][C:9]=1[OH:31]

Participants

Reactant 2

HCID 12251Methoxyacetic Acid

HCID 69055503HCID 69055503, compound

Product 1

HCID 69063687HCID 69063687, compoundYield 49%

Procedure

The procedure described in Example 3 (preparation of starting materials) was repeated using methoxyacetic acid and 2-chloro-4-[(5-{[(2S)-2-(methylamino)propyl]oxy}quinazolin-4-yl)amino]phenol (obtained as described in Example 56, preparation of starting materials) to give N-[(1S)-2-({4-[(3-chloro-4-hydroxyphenyl)amino]quinazolin-5-yl}oxy)-1-methylethyl]-2-methoxy-N-methylacetamide in 49% yield; Mass spectrum MH+ 429.2.

Workup

customThe procedure described in Example 3 (preparation of starting materials)

Sources & evidence

ORD record: ord-690180356e62419fb1bc2aa8a87d209f
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07625908B2

Reaction notes

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