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HRID1864340

反应详情

EQUATION

反应方程式

HRID 1864340 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H](O)CN
HCID439938

(R)-1-Amino-2-propanol

C3H9NO

结构：Cc1ccc(Oc2ccc(Nc3ncnc4cccc(F)c34)cc2C)cn1
HCID69024197

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(Oc2ccc(Nc3ncnc4cccc(O[C@H](C)CN)c34)cc2C)cn1
HCID69058603

未命名化合物

收率 77%

PROCEDURE

实验过程

The procedure described in Example 103 (preparation of starting materials) was repeated using 5-fluoro-N-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}quinazolin-4-amine (obtained as described in Example 103, preparation of starting materials) and (2R)-1-aminopropan-2-ol to give 5-[(1R)-2-amino-1-methylethoxy]-N-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}quinazolin-4-amine in 77% yield; Mass spectrum: MH+ 416

WORKUP

后处理

  1. customThe procedure described in Example 103 (preparation of starting materials)