Sodium Iodide → HCID 25028837, compound

HRID 1864403Notes

Reaction equation

HRID 1864403 reaction equation
[C:1]1([S:7]([N@:10]2[CH2:12][CH:11]2[C:13]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=3[CH3:28])[CH2:17][CH2:16]2)=[O:14])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I-].[Na+].[F:31][C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[CH:34][C:33]=1[N:39]=[C:40]=[O:41]>>[C:1]1([S:7]([N:10]2[CH2:12][C@@H:11]([C:13]([N:15]3[CH2:16][CH2:17][N:18]([C:21]4[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=4[CH3:28])[CH2:19][CH2:20]3)=[O:14])[N:39]([C:33]3[CH:34]=[CH:35][C:36]([F:38])=[CH:37][C:32]=3[F:31])[C:40]2=[O:41])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 5932582,4-Difluorophenyl isocyanateHCID 178425107HCID 178425107, compound

Product 1

HCID 25028837HCID 25028837, compound

Procedure

In analogy to example 2, ((S)-1-benzenesulfonyl-aziridin-2-yl)-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-methanone (example 21, step 3) was reacted with sodium iodide and 2,4-difluorophenylisocyanate to give the title compound as a colorless solid. MS: 554.8 ([M+H]+)

Sources & evidence

ORD record
ord-61b5a4a0bc3a4b8e824da9c301beb143
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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