反应详情

A suspension of (RS)-4-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-3-phenyl-1-(toluene-4-sulfonyl)-imidazolidin-2-one (example 10, 0.59 g) and magnesium powder (0.215 g) in methanol (25 ml) was refluxed for 7 h and stirred at room temperature for 18 h. The mixture was filtered and the filtrate was concentrated. The product was purified by chromatography ((SiO2, ethyl acetate=>ethyl acetate/methanol 95:5) to give (RS)-5-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-phenyl-imidazolidin-2-one (0.292 g) as a colorless solid.

1. temperaturewas refluxed for 7 h
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated
4. customThe product was purified by chromatography ((SiO2, ethyl acetate=>ethyl acetate/methanol 95:5)