Sodium hydride → HCID 25029061, compound

HRID 1864410Notes

Reaction equation

HRID 1864410 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([CH:17]2[N:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:20](=[O:28])[NH:19][CH2:18]2)=[O:16])[CH2:11][CH2:10]1.[H-].[Na+].[CH:31]([S:34](Cl)(=[O:36])=[O:35])([CH3:33])[CH3:32]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([CH:17]2[CH2:18][N:19]([S:34]([CH:31]([CH3:33])[CH3:32])(=[O:36])=[O:35])[C:20](=[O:28])[N:21]2[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 824082-Propanesulfonyl chlorideHCID 67142096(RS)-5-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-phenyl-imidazolidin-2-one

Product 1

HCID 25029061HCID 25029061, compound

Procedure

In analogy to example 33, (RS)-5-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-phenyl-imidazolidin-2-one (example 33, step 1) was reacted with sodium hydride and isopropylsulfonyl chloride to give the title compound as an off-white solid. MS: 485.2 ([M+H]+)

Sources & evidence

ORD record
ord-e221052865e5418e9c0c9bef71aa7ecb
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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