Sodium hydride → HCID 25029062, compound

HRID 1864411Notes

Reaction equation

HRID 1864411 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([CH:17]2[N:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:20](=[O:28])[NH:19][CH2:18]2)=[O:16])[CH2:11][CH2:10]1.[H-].[Na+].[CH2:31]([S:35](Cl)(=[O:37])=[O:36])[CH2:32][CH2:33][CH3:34]>>[CH2:31]([S:35]([N:19]1[CH2:18][CH:17]([C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:3]3[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=3[CH3:1])[CH2:10][CH2:11]2)=[O:16])[N:21]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:20]1=[O:28])(=[O:37])=[O:36])[CH2:32][CH2:33][CH3:34]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 754301-Butanesulfonyl chlorideHCID 67142096(RS)-5-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-phenyl-imidazolidin-2-one

Product 1

HCID 25029062HCID 25029062, compound

Procedure

In analogy to example 33, (RS)-5-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-phenyl-imidazolidin-2-one (example 33, step 1) was reacted with sodium hydride and 1-butanesulfonyl chloride to give the title compound as an off-white solid. MS: 499.0 ([M+H]+)

Sources & evidence

ORD record
ord-d669c98ab9564776baafd30ba8c13515
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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