Triphenylphosphine → HCID 178498699, compound

HRID 1864424Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:17])[C@@H:4]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:10])=[O:9])[CH2:5]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>>[CH3:1][O:2][C:3]([CH:4]1[CH2:5][N@@:7]1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:17]

Participants

Reactant 3

HCID 11776Triphenylphosphine

HCID 5462977Diethyl azodicarboxylate

HCID 11097280HCID 11097280, compound

Product 1

HCID 178498699HCID 178498699, compound

Procedure

In analogy to example 1, (S)-2-benzenesulfonylamino-3-hydroxy-propionic acid methyl ester was treated with triphenylphosphine and DEAD to give (S)-1-benzenesulfonyl-aziridine-2-carboxylic acid methyl ester.

Sources & evidence

ORD record: ord-beaab9b7fa25407e97b981f723d2bfb7
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07625902B2

Reaction notes

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