Sodium hydride → 4-[4-(2,5-Dimethyl-phenyl)-piperazine-1-carbonyl]-3-phenyl-1-(pyridine-2-sulfonyl)-imidazolidin-2-one

HRID 1864447Notes

Reaction equation

HRID 1864447 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([CH:17]2[N:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:20](=[O:28])[NH:19][CH2:18]2)=[O:16])[CH2:11][CH2:10]1.[H-].[Na+].[N:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[S:37](Cl)(=[O:39])=[O:38]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([CH:17]2[CH2:18][N:19]([S:37]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][N:31]=3)(=[O:39])=[O:38])[C:20](=[O:28])[N:21]2[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 3787675Pyridine-2-sulfonyl ChlorideHCID 67142096(RS)-5-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-phenyl-imidazolidin-2-one

Product 1

HCID 250307004-[4-(2,5-Dimethyl-phenyl)-piperazine-1-carbonyl]-3-phenyl-1-(pyridine-2-sulfonyl)-imidazolidin-2-one

Procedure

In analogy to example 33, (RS)-5-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-phenyl-imidazolidin-2-one (example 33, step 1) was reacted with sodium hydride and pyridine-2-sulfonyl chloride to give the title compound as a colorless solid. MS: 520.2 ([M+H]+)

Sources & evidence

ORD record
ord-a8f840e0b4b64d3ea6fab3598d5ef67a
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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