HRID1864460

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5238

Sodium Iodide

INa

HCID51711953

未命名化合物

结构：O=C(C1C[N@@]1S(=O)(=O)c1ccccc1Cl)N1CCN(c2ncccc2C(F)(F)F)CC1

HCID178519786

未命名化合物

PRODUCTS

生成物

结构：O=C([C@@H]1CN(S(=O)(=O)c2ccccc2Cl)C(=O)N1C1CCOCC1)N1CCN(c2ncccc2C(F)(F)F)CC1

HCID25027493

未命名化合物

PROCEDURE

实验过程

In analogy to example 2, [(S)-1-(2-chloro-benzenesulfonyl)-aziridin-2-yl]-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-methanone (example 72, step 3) was reacted with sodium iodide and tetrahydropyran-4-yl-isocyanate to give the title compound as a light yellow solid. MS: 601.9 ([M+H]+)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bde23e75d08e46879cf6969612581aa9
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07625902B2
来源说明: uspto-grants-2009_12

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N@:11]1[CH2:13][CH:12]1[C:14]([N:16]1[CH2:21][CH2:20][N:19]([C:22]2[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:18][CH2:17]1)=[O:15])(=[O:10])=[O:9].[I-].[Na+].[O:34]1[CH2:39][CH2:38][CH:37]([N:40]=[C:41]=[O:42])[CH2:36][CH2:35]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:13][C@@H:12]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([C:28]([F:30])([F:29])[F:31])=[CH:26][CH:25]=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])[N:40]([CH:37]2[CH2:38][CH2:39][O:34][CH2:35][CH2:36]2)[C:41]1=[O:42])(=[O:10])=[O:9]