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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1864464Generated: October 30, 2026

Lithium Hydroxide → (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid

https://huagongshe.com/reaction/1864464

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
Reactant(RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid methyl esterHCID 67142255—
Product(RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acidHCID 67141181—

Reaction Steps

In analogy to example 1, (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid methyl ester was hydrolyzed using lithium hydroxide solution to give (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07625902B2
Source datasetuspto-grants-2009_12
ORD IDord-228112c883c94520b8d092c076b37fb8
Source noteuspto-grants-2009_12