Lithium Hydroxide → (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid

HRID 1864464Notes

Reaction equation

C[O:2][C:3]([CH:5]1[CH2:9][N:8]([S:10]([CH:13]([CH3:15])[CH3:14])(=[O:12])=[O:11])[C:7](=[O:16])[N:6]1[C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=1[F:24])=[O:4].[OH-].[Li+]>>[F:24][C:18]1[CH:19]=[C:20]([F:23])[CH:21]=[CH:22][C:17]=1[N:6]1[CH:5]([C:3]([OH:4])=[O:2])[CH2:9][N:8]([S:10]([CH:13]([CH3:14])[CH3:15])(=[O:12])=[O:11])[C:7]1=[O:16]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 67142255(RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid methyl ester

Product 1

HCID 67141181(RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid

Procedure

In analogy to example 1, (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid methyl ester was hydrolyzed using lithium hydroxide solution to give (RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid.

Sources & evidence

ORD record: ord-228112c883c94520b8d092c076b37fb8
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07625902B2

Reaction notes

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