1,4-Dioxane hydrochloride → HCID 86597085, compound

HRID 1864492Notes

Reaction equation

HRID 1864492 reaction equation
C(OC([N:8]1[CH2:13][C@H:12]([CH3:14])[N:11]([C:15]#[N:16])[C@H:10]([CH3:17])[CH2:9]1)=O)(C)(C)C.[ClH:18].O1CCOCC1>C1COCC1>[ClH:18].[CH3:17][C@H:10]1[CH2:9][NH:8][CH2:13][C@@H:12]([CH3:14])[N:11]1[C:15]#[N:16]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59710157HCID 59710157, compound

Product 1

HCID 86597085HCID 86597085, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-Cyano-cis-3,5-dimethylpiperazine-1-carboxylic acid tert-butyl ester (1.0 g) in 10 mL THF was treated with 4.0 N HCl/dioxane (25 mL), stirred for five hours and concentrated to provide 1.1 g of the title compound. 1H NMR (DMSO-D6, 300 MHz) δ ppm 1.24 (d, 6H, J=6.6 Hz), 2.65 (q, 2H, J=11.1 Hz), 3.27 (d, 2H, J=12.2 Hz), 3.63 (m, 2H); 13C (DMSO, 75 MHz) 16.73 (2C), 46.81 (2C), 50.80 (2C), 104.20.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-a3c32b68414a4f9fbe6f0510942bf5b2
Source dataset
uspto-grants-2009_12
Patent number
US07625909B2

Reaction notes

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