1,4-Dioxane hydrochloride → N-(azetidin-3-yl)methanesulfonamide

HRID 1864511Notes

Reaction equation

HRID 1864511 reaction equation
C1(C(C2C=CC=CC=2)[N:8]2[CH2:11][CH:10]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH2:9]2)C=CC=CC=1.Cl.O1CCOCC1.[H][H]>CO>[NH:8]1[CH2:11][CH:10]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH2:9]1

Participants

5

Reactant 3

HCID 204431481,4-Dioxane hydrochlorideHCID 57436107N-[1-(diphenylmethyl)-3-azetidinyl]methanesulfonamideHCID 178418361HCID 178418361, compound

Product 1

HCID 59710124N-(azetidin-3-yl)methanesulfonamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-[1-(diphenylmethyl)-3-azetidinyl]-methanesulfonamide (185 mg, 0.585 mmol) in MeOH (10 mL) was treated with 1 mL of 4.0 N HCl/dioxane and then reacted overnight with hydrogen gas at 50 psi. The reaction mixture was then filtered through a pad of Celite and used without further purification.

Workup

  1. filtrationThe reaction mixture was then filtered through a pad of Celite
  2. customused without further purification

Sources & evidence

ORD record
ord-153bb1bc21c94d76bb5118ec5d780820
Source dataset
uspto-grants-2009_12
Patent number
US07625909B2

Reaction notes

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