HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → N-(azetidin-3-yl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | N-[1-(diphenylmethyl)-3-azetidinyl]methanesulfonamide | HCID 57436107 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(azetidin-3-yl)methanesulfonamide | HCID 59710124 | — |
Reaction Steps
A solution of N-[1-(diphenylmethyl)-3-azetidinyl]-methanesulfonamide (185 mg, 0.585 mmol) in MeOH (10 mL) was treated with 1 mL of 4.0 N HCl/dioxane and then reacted overnight with hydrogen gas at 50 psi. The reaction mixture was then filtered through a pad of Celite and used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07625909B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-153bb1bc21c94d76bb5118ec5d780820 |
| Source note | uspto-grants-2009_12 |