2-Naphthyl isocyanate → HCID 67147786, compound

HRID 1864583Notes

Reaction equation

HRID 1864583 reaction equation
[CH2:1]([O:3][C@@H:4]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][CH3:23])[N:17]=2)=[CH:12][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6])[CH3:2].[CH:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26][C:25]=1[N:34]=[C:35]=[O:36]>>[CH2:1]([O:3][C@@H:4]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N:22]([CH3:23])[C:35]([NH:34][C:25]3[CH:26]=[CH:27][C:28]4[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH:24]=3)=[O:36])[N:17]=2)=[CH:12][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6])[CH3:2]

Participants

3

Reactant 2

HCID 167182-Naphthyl isocyanateHCID 67148263HCID 67148263, compound

Product 1

HCID 67147786HCID 67147786, compoundYield 62%

Procedure

In a manner similar to that of Example 7(i), starting with 0.4 g (0.8 mmol) of methyl 2(S)-ethoxy-3-[4-(6-methylaminopyrid-2-yl)phenyl]propanoate and 2-naphthyl isocyanate, 0.2 g (62%) of methyl 2(S)-ethoxy-3-{4-[6-(1-methyl-3-naphthalen-2-ylureido)pyrid-2-yl]phenyl}propionate is obtained.

Sources & evidence

ORD record
ord-ba7c8a3d0cb84b22b9601121b6a16b0d
Source dataset
uspto-grants-2009_12
Patent number
US07625914B2

Reaction notes

Loading…