反应详情

A mixture of 4-chloro-3-trifluoromethylphenyl-isothiocyanate (20 μL, 0.12 mmol) and 7-(4-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one (29 mg, 0.12 mmol) in anhydrous THF (2 mL) was stirred at room temperature for 3 days. The solvent was evaporated and the solid residue was washed with DCM to afford the title compound (47 mg, 82%). 1H-NMR (δ, ppm, DMSO-d6): 6.40 (d, 1H, HPy,6, J=5.8 Hz), 7.15 (d, 2H, Harom,Ph,3+5, J=8.70 Hz), 7.54 (d, 2H, Harom,Ph,2+6, J=8.75 Hz), 7.67 (d, 1H, HPy,6, J=8.55 Hz), 7.80 (broad s, 2H, Harom′), 8.08 (s, 1H, Harom′), 10.03 (s, 1H, NHthiourea,1), 10.10 (s, 1H, NHthiourea,3), 11.18 (s, 1H, NHPy3), 11.36 (s, 1H, NHPy2).

1. customThe solvent was evaporated
2. washthe solid residue was washed with DCM