Methanesulfonic Acid → 849675-87-2

HRID 1864680Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][N:8]([CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]3[N:27]=[N:26][C:25]([C:28]4[CH:33]=[C:32]([O:34][CH3:35])[C:31]([O:36][CH3:37])=[CH:30][C:29]=4[NH:38][C:39]([C:41]4[O:42][C:43]5[C:48]([C:49](=[O:51])[CH:50]=4)=[CH:47][CH:46]=[CH:45][CH:44]=5)=[O:40])=[N:24]3)=[CH:19][CH:18]=1)[CH2:7][CH2:6]2.[CH3:52][S:53]([OH:56])(=[O:55])=[O:54]>>[CH3:52][S:53]([OH:56])(=[O:55])=[O:54].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][N:8]([CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]3[N:27]=[N:26][C:25]([C:28]4[CH:33]=[C:32]([O:34][CH3:35])[C:31]([O:36][CH3:37])=[CH:30][C:29]=4[NH:38][C:39]([C:41]4[O:42][C:43]5[C:48]([C:49](=[O:51])[CH:50]=4)=[CH:47][CH:46]=[CH:45][CH:44]=5)=[O:40])=[N:24]3)=[CH:19][CH:18]=1)[CH2:7][CH2:6]2

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 11399764N-[2-[2-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide

Product 1

HCID 76971350849675-87-2Yield 80%

Procedure

The procedure of Example 33 was repeated except for using 1.2 g of the compound obtained in Example 21 and 0.12 ml of methanesulfonic acid as starting materials to obtain 1.1 g of the title compound (yield 80%).

Sources & evidence

ORD record: ord-e02afb865da6401c9a0c8b8cdfcdc5a4
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07625926B2

Reaction notes

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