Hydrochloric Acid → methyl (2S,3S)-3-hydroxypyrrolidine-2-carboxylate hydrochloride
Reaction equation
[ClH:1].[OH:2][C@H:3]1[CH2:7][CH2:6][NH:5][C@@H:4]1[C:8]([OH:10])=[O:9].[CH3:11]O>>[ClH:1].[CH3:11][O:9][C:8]([C@@H:4]1[C@@H:3]([OH:2])[CH2:7][CH2:6][NH:5]1)=[O:10]Participants
4
Conditions
- Temperature
- 0 °C
Procedure
Hydrogen chloride gas was bubbled through a suspension of trans-3-hydroxy-L-proline (50.0 g, 0.380 mol) in MeOH (600 mL) cooled to 0° C. for 10 min. The resulting clear solution was stirred at rt for 4 h, then concentrated carefully under reduced pressure (white precipitates formed during the concentration). The resulting white solid was dried under vacuum overnight to afford the title compound (68.3 g) as a white solid.
Workup
- concentrationconcentrated carefully under reduced pressure (
- customwhite precipitates
- customformed during the concentration)
- customThe resulting white solid was dried under vacuum overnight
Sources & evidence
- ORD record
- ord-58a299e7116f4219bbbd255e74085eba
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07625923B2
Reaction notes
Loading…