HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-isocyanato-3-methylbenzonitrile → (2R,3S)-3-(tert-Butyldimethylsilanyloxy)-2-hydroxymethyl-2-methylpyrrolidine-1-carboxylic Acid Tert-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-isocyanato-3-methylbenzonitrile | HCID 16731849 | — |
| Reactant | (2S,3R)-3-(tert-Butyldimethylsilanyloxy)-2-hydroxymethyl-2-methylpyrrolidine-1-carboxylic Acid Tert-Butyl Ester | HCID 69019276 | — |
| Product | (2R,3S)-3-(tert-Butyldimethylsilanyloxy)-2-hydroxymethyl-2-methylpyrrolidine-1-carboxylic Acid Tert-Butyl Ester | HCID 59754210 | 68.9% |
Reaction Steps
Compound 4D (84.0 mg) was prepared from compound 4C (122 mg) and compound 1G (82.0 mg) following procedures analogous to those used in Example 1 for the preparation of compound 1H. LCMS: m/z 438 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07625923B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-312d365331d84c9a94a033dcd6674f94 |
| Source note | uspto-grants-2009_12 |