反应详情

温度

50 °C

DMF (20 mL) is added to 4-(1H-Imidazol-2-yl)-pyridine (930 mg, 6.4 mmol), sodium carbonate (1.92 g, 20 mmol), and 3-nitrobenzyl chloride (1.71 g, 10 mmol) and the mixture is warmed to 50° C. for 4 h. Water (100 mL) is added and the corresponding mixture is extracted with EtOAc (100 mL), dried over anhydrous sodium sulfate, and crude solution is concentrated under reduced pressure. The organics are dissolved in DCM and filtered through a plug of silica eluting first with DCM, and then washing with 20% MeOH:80% DCM to afford 4-[1-(3-Nitro-benzyl)-1H-imidazol-2-yl]-pyridine as an off-white solid.

1. extractionthe corresponding mixture is extracted with EtOAc (100 mL)
2. dry with materialdried over anhydrous sodium sulfate, and crude solution
3. concentrationis concentrated under reduced pressure
4. dissolutionThe organics are dissolved in DCM
5. filtrationfiltered through a plug of silica eluting first with DCM
6. washwashing with 20% MeOH