Potassium Carbonate → HCID 135843048, compound

HRID 1864738Notes

Reaction equation

HRID 1864738 reaction equation
C([O-])([O-])=O.[K+].[K+].[CH3:7][O:8][C:9]1[CH:42]=[CH:41][C:12]2[C:13]([C:16]3[C:24]4[C:19](=[CH:20][C:21]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:22][CH:23]=4)[N:18](S(C4C=CC(C)=CC=4)(=O)=O)[C:17]=3[CH3:40])=[N:14][O:15][C:11]=2[CH:10]=1>CO>[CH3:7][O:8][C:9]1[CH:42]=[CH:41][C:12]2[C:13]([C:16]3[C:24]4[C:19](=[CH:20][C:21]([O:25][C:26]([F:28])([F:27])[F:29])=[CH:22][CH:23]=4)[NH:18][C:17]=3[CH3:40])=[N:14][O:15][C:11]=2[CH:10]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 18438968HCID 18438968, compound

Product 1

HCID 135843048HCID 135843048, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

K2CO3 (3 eq) and 10 (2.5 g, 4.8 mmol) were heated to reflux in aqueous methanol for 2 hours at which time starting material had been consumed. The reaction mixture was concentrated, diluted with EtOAc and washed with brine. The organic layer was dried over Na2SO4 and concentrated. The residue was purified via flash chromatography eluting with 20% EtOAc/hexanes to provide the product as a pale green solid.

Workup

  1. customhad been consumed
  2. concentrationThe reaction mixture was concentrated
  3. additiondiluted with EtOAc
  4. washwashed with brine
  5. dry with materialThe organic layer was dried over Na2SO4
  6. concentrationconcentrated
  7. customThe residue was purified via flash chromatography
  8. washeluting with 20% EtOAc/hexanes

Sources & evidence

ORD record
ord-e49c295ef76741d98a8cc40a0318e328
Source dataset
uspto-grants-2009_12
Patent number
US07625933B2

Reaction notes

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