Sulfanilamide → HCID 68487849, compound

HRID 18648Notes

Reaction equation

[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH3:10][C:11](=O)[CH:12]=[CH2:13].[NH2:15][S:16]([C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)(=[O:18])=[O:17]>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]2[N:25]([C:22]3[CH:23]=[CH:24][C:19]([S:16]([NH2:15])(=[O:17])=[O:18])=[CH:20][CH:21]=3)[C:11]([CH3:10])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 5333Sulfanilamide

HCID 6570Methyl vinyl ketone

HCID 707414-Bromobenzaldehyde

Product 1

HCID 68487849HCID 68487849, compound

Procedure

4-Bromobenzaldehyde and but-3-en-2-one were treated according to the procedure outlined in General Procedure C followed by subjecting the resulting product to conditions outlined in General Procedure D along with p-aminosulfonyl phenylamine to obtain the titled compound. 1H NMR (CDCl3) δ ppm 2.15 (3H), 4.81 (2H), 6.15 (1H), 6.29 (1H), 6.95-7.85 (8H); MS (ESI) m/z 391/393 (M+H)

Sources & evidence

ORD record: ord-55d07d2dbfdb47ff89085fd991994fa3
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07741364B2

Reaction notes

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