反应详情

1 mL of 95% aqueous TFA was added to a solution of 6-(5-{[(4-fluoro-benzyl)-(1-methyl-piperidin-4-yl)-amino]-methyl}-furan-3-yl)-3-trityl-3H-benzooxazol-2-one (64 mg, 0.09 mmol) in 2 mL of dichloromethane, and the resulting mixture was stirred at room temperature for 1 h. The solvent was removed to afford the crude product. Purification was achieved via flash silica gel chromatography (elution with DCM:MeOH:AcOH:water). The pooled fractions were combined and the solvent was removed in vacuo with co-evaporation of residual AcOH using toluene to give 16 mg of product. LC/MS (long run): Retention time, 3.83 min; (M+H)=436.

1. customThe solvent was removed
2. customto afford the crude product
3. customPurification
4. washwas achieved via flash silica gel chromatography (elution with DCM:MeOH:AcOH:water)
5. customthe solvent was removed in vacuo with co-evaporation of residual AcOH