反应详情

To a cooled (0° C.) solution of methyl 1-({(3S)-3-[(tert-butoxycarbonyl)amino]-3-phenylpropyl}amino)cyclopentanecarboxylate from Step C (0.920 g, 2.44 mmol) in MeOH (49 mL) was added excess anhydrous hydrogen chloride gas. After 30 min the solution was purged with dry nitrogen for about 40 min. The solvent was then removed in vacuo to provide a solid/oil mix. Additional MeOH (50 mL) was then added and subsequently removed in vacuo to provide the title compound. MS: nm/z=277 (M+1).

1. customAfter 30 min the solution was purged with dry nitrogen for about 40 min
2. customThe solvent was then removed in vacuo
3. customto provide a solid/oil
4. additionmix
5. customsubsequently removed in vacuo