反应详情

温度

75 °C

Add 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzenecarbonitrile (0.916 grams, 0.003 moles, prepared in preparation 58), 4-cyano-5-ethyl-3-iodo-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester (0.996 grams, 0.003 moles, prepared in preparation 38), isopropyl acetate (14 mL) and ethanol (6 mL) to a 100 mL 3-neck flask. Stir the mixture under a nitrogen atmosphere and add palladium black (0.0319 grams, 0.0003 moles). Add a solution of potassium carbonate (0.663 grams, 0.0048 moles) in water (6 mL). Heat the mixture to reflux at 75° C. for 135 minutes. Add bis(acetato)bis(triphenylphosphine)palladium (II) (0.045 grams, 0.00006 moles) and continue heating at reflux for an additional 105 minutes. Add a solution of potassium carbonate (0.16 grams, 0.00116 moles) in water and continue heating at reflux for an additional 195 minutes. Cool the mixture to room temperature and stir for about 16 hours. Warm the mixture to 75° C. and filter to remove palladium black. Transfer the filtrate to a separatory funnel and add acetone (20 mL) to redissolve a precipitate and then separate the phases. Discard the aqueous phase. Concentrate the organic phase to a solid under reduced pressure (15-25 mm) and suspend the solid in ethanol (3 mL) and water (7 mL). Filter the suspension to recover the solid, and transfer the solid to a 20 mL vial. Add ethanol (12 mL) and warm to reflux. Slowly cool the resulting solution to about 23° C. and filter the resulting suspension to recover the precipitate. Dry the solid at 45° C. under reduced pressure (15-25 mm) to provide the title compound (0.72 g, 0.00188 moles) in 62.6% yield. 1H NMR (CDCl3, 500 MHz): δ 7.77 (app d, 2H, J=8); 7.66 (app. td, 1H. J=117.5): 7.57 (m, 3H), 7.49-7.43 (m,3H); 4.10 (q, 2H, J=6.5); 3.91 (s, 3H); 2.87 (q, 2H, J=8); 1.32 (t, 3H, J=7.5); 1.04 (t, 3H, J=7).

1. temperatureHeat the mixture
2. temperatureat reflux for an additional 105 minutes
3. temperaturecontinue heating
4. temperatureat reflux for an additional 195 minutes
5. temperatureCool the mixture to room temperature
6. stirringstir for about 16 hours
7. temperatureWarm the mixture to 75° C.
8. filtrationfilter
9. customto remove palladium black
10. additionadd acetone (20 mL)
11. dissolutionto redissolve a precipitate
12. customseparate the phases
13. concentrationConcentrate the organic phase to a solid under reduced pressure (15-25 mm)
14. filtrationFilter the suspension
15. customto recover the solid
16. temperatureAdd ethanol (12 mL) and warm to reflux
17. temperatureSlowly cool the resulting solution to about 23° C.
18. filtrationfilter the resulting suspension
19. customto recover the precipitate
20. customDry the solid at 45° C. under reduced pressure (15-25 mm)