4-Cyano-3-[4-(2-cyanophenyl)phenyl]-5-ethyl-1-methylpyrrole-2-carboxylic acid → 4-Cyano-3-[4-(2-cyanophenyl)phenyl]-5-ethyl-1-methylpyrrole-2-carboxylic acid dimethylsulfoxide

HRID 1865126Notes

Reaction equation

HRID 1865126 reaction equation
[C:1]([C:3]1[C:4]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]#[N:27])=[CH:16][CH:15]=2)=[C:5]([C:11]([OH:13])=[O:12])[N:6]([CH3:10])[C:7]=1[CH2:8][CH3:9])#[N:2].[CH3:28][S:29]([CH3:31])=[O:30].O>>[CH3:28][S:29]([CH3:31])=[O:30].[C:1]([C:3]1[C:4]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]#[N:27])=[CH:16][CH:15]=2)=[C:5]([C:11]([OH:13])=[O:12])[N:6]([CH3:10])[C:7]=1[CH2:8][CH3:9])#[N:2]

Participants

3

Reactant 2

HCID 112912124-Cyano-3-[4-(2-cyanophenyl)phenyl]-5-ethyl-1-methylpyrrole-2-carboxylic acidHCID 23503278(Methanesulfinyl)methane--water (1/1)

Product 1

HCID 690237754-Cyano-3-[4-(2-cyanophenyl)phenyl]-5-ethyl-1-methylpyrrole-2-carboxylic acid dimethylsulfoxide

Procedure

4-Cyano-3-[4-(2-cyanophenyl)phenyl]-5-ethyl-1-methylpyrrole-2-carboxylic acid, Form I (300 mg) is slurried at RT in a 1:1 v/v mixture (8 mL) of DMSO-H2O for approximately 22 hours, yielding the title compound as a clumpy, granular solid.

Sources & evidence

ORD record
ord-9fbb33d9f9844d16863109bac9518d12
Source dataset
uspto-grants-2009_12
Patent number
US07625932B2

Reaction notes

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