反应详情

温度

60 °C

2,4-Difluoro-3-methoxybenzoic acid (18.8 g) was placed in a reaction vessel and was suspended in 100 ml of toluene added thereto at room temperature. After dropwise addition of 0.5 mL of N,N-dimethylformamide, 14.6 mL of thionyl chloride was added dropwise, and the resulting mixture was heated to 60° C. with stirring. After 7 hours, 50 mL of ethanol was added and an insoluble matter was filtered out. The filtrate was washed with water and saturated brine, and dried with anhydrous sodium sulfate. The solvent was distilled away to give the title compound (21.4 g) as a pale yellow oil.

1. additionadded
2. customat room temperature
3. additionwas added dropwise
4. filtrationan insoluble matter was filtered out
5. washThe filtrate was washed with water and saturated brine
6. dry with materialdried with anhydrous sodium sulfate
7. distillationThe solvent was distilled away