HCID 22278911, compound → HCID 10285824, compound

HRID 1865249Notes

Reaction equation

HRID 1865249 reaction equation
[C:1]([NH:4][CH:5]1[CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7][C:6]1([CH3:19])[CH3:18])(=[O:3])[CH3:2]>CO.[H][H].[OH-].[OH-].[Pd+2]>[C:1]([NH:4][CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][C:6]1([CH3:19])[CH3:18])(=[O:3])[CH3:2]

Participants

5

Reactant 1

HCID 22278911HCID 22278911, compound

Product 1

HCID 10285824HCID 10285824, compound

Reagents, catalysts & solvents 3

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

A mixture of 20% Pd(OH)2 on carbon (0.3 g) and 4-acetylamino-1-benzyl-3,3-dimethyl piperidine (1.8 g, 6.92 mmol) in methanol (20 ml) was stirred in hydrogen atmosphere (1 atm.) at 35° C. for 6 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-acetylamino-3,3-dimethylpiperidine. Yield 1.0 g (90%), C9H18N2O, m/z 171 (M+1).

Workup

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated to dryness

Sources & evidence

ORD record
ord-99e0d03024664917a29270e92d90827b
Source dataset
uspto-grants-2009_12
Patent number
US07626032B2

Reaction notes

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