HCID 22278884, compound → HCID 22278892, compound

HRID 1865280Notes

Reaction equation

HRID 1865280 reaction equation
[NH2:1][CH:2]1[CH:7]([CH2:8][CH3:9])[CH2:6][N:5](CC2C=CC=CC=2)[CH2:4][C:3]1([CH2:18][CH3:19])[CH3:17]>CO.[H][H].[OH-].[OH-].[Pd+2]>[NH2:1][CH:2]1[CH:7]([CH2:8][CH3:9])[CH2:6][NH:5][CH2:4][C:3]1([CH2:18][CH3:19])[CH3:17]

Participants

5

Reactant 1

HCID 22278884HCID 22278884, compound

Product 1

HCID 22278892HCID 22278892, compound

Reagents, catalysts & solvents 3

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

A mixture of 20% Pd(OH)2 on carbon (0.3 g) and 4-amino-1-benzyl-3,5-diethyl-3-methylpiperidine (2.1 g, 8.07 mmol) in methanol (50 ml) was stirred in hydrogen atmosphere (4 atm.) at 45° C. for 4 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-amino-3,5-diethyl-3-methyl-piperidine as an oil. Yield 1.2 g (88%), C10H22N2, m/z 171 (M+1).

Workup

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated to dryness

Sources & evidence

ORD record
ord-e71e70c809154638b105d5d66aa754af
Source dataset
uspto-grants-2009_12
Patent number
US07626032B2

Reaction notes

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