反应详情

Methyl chloroformate(42 μL, 0.54 mmol) was added to a solution of 5-chloro-2-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]benzamide 1 sodium salt(200 mg, 0.49 mmol) in tetrahydrofuran(5 mL) under ice cooling, and the mixture was stirred at room temperature for 10 minutes. The reaction mixture was poured into water and extracted with ethyl acetate. After the ethyl acetate layer was washed successively with water and brine, dried over anhydrous sodium sulfate, the residue obtained by evaporation of the solvent under reduced pressure was washed with n-hexane under suspension to give the title compound(171.2 mg, 78.6%) as a white solid.

1. extractionextracted with ethyl acetate
2. washAfter the ethyl acetate layer was washed successively with water and brine
3. dry with materialdried over anhydrous sodium sulfate
4. customthe residue obtained by evaporation of the solvent under reduced pressure
5. washwas washed with n-hexane under suspension