Trifluoroacetic acid → HCID 67487982, compound

HRID 1865433Notes

Reaction equation

HRID 1865433 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:13]=[C:12]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[N:20]=[CH:19][CH:18]=[N:17]4)[N:11]([CH:24]([C:26]3[CH:38]=[CH:37][C:29]([C:30]([O:32]C(C)(C)C)=[O:31])=[CH:28][CH:27]=3)[CH3:25])[N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:8][C:6]1[CH:5]=[C:4]([C:9]2[CH:13]=[C:12]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[N:20]=[CH:19][CH:18]=[N:17]4)[N:11]([CH:24]([C:26]3[CH:38]=[CH:37][C:29]([C:30]([OH:32])=[O:31])=[CH:28][CH:27]=3)[CH3:25])[N:10]=2)[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68568772HCID 68568772, compound

Product 1

HCID 67487982HCID 67487982, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The intermediate from step F (40 mg, 0.07 mmol) was dissolved in 1:1 CH2Cl2:TFA (4 mL) and stirred at room temperature for 30 minutes. The reaction mixture was concentrated in vacuo and azeotroped with toluene (3×). The resulting light yellow solid was used without further purification. LC-MS: 4.18 min. (M+H)=490.35.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customazeotroped with toluene (3×)
  3. customThe resulting light yellow solid was used without further purification
  4. custom4.18 min. (M+H)=490.35

Sources & evidence

ORD record
ord-b84e30fb9b3e4361b9b402a590016808
Source dataset
uspto-grants-2009_12
Patent number
US07625938B2

Reaction notes

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