Thioglycolic Acid → HCID 178489398, compound

HRID 1865620Notes

Reaction equation

HRID 1865620 reaction equation
C(OC([NH:8][C:9]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[C:20]3[C:26]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[O:33][CH3:34])=[N:25][N:24](COCC[Si](C)(C)C)[C:21]3=[N:22][CH:23]=2)=[CH:14][C:10]=1[C:11]([OH:13])=[O:12])=O)(C)(C)C.Cl(O)(=O)(=O)=O.SCC(O)=O>C(O)(=O)C.O>[NH2:8][C:9]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[C:20]3[C:26]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[O:33][CH3:34])=[N:25][NH:24][C:21]3=[N:22][CH:23]=2)=[CH:14][C:10]=1[C:11]([OH:13])=[O:12]

Participants

6

Reactant 3

HCID 1133Thioglycolic AcidHCID 24247Perchloric AcidHCID 579759012-tert-butoxycarbonylamino-5-[3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-benzoic acid

Product 1

HCID 178489398HCID 178489398, compoundYield 82.4%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Conditions

Temperature
80 °C

Procedure

200 mg (0.34 mmol) of 2-tert-butoxycarbonylamino-5-[3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-benzoic acid were dissolved in 5 mL of glacial acetic acid. 500 μL of 70% perchloric acid was added and the mixture left at ambient temperature for 24 h. 3 mL of water and 300 μL of mercaptoacetic acid was added and the mixture heated to 80° C. for 20 h. The resulting mixture was cooled to room temperature and diluted with 50 mL of water. The resulting precipitate was filtered off and dried by suction to afford 101 mg (0.28 mmol, 82%) of 2-amino-5-[3-(2-methoxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-benzoic acid as a red-brown solid. MS: m/z 361.1 (M+H+).

Workup

  1. temperatureThe resulting mixture was cooled to room temperature
  2. filtrationThe resulting precipitate was filtered off
  3. customdried by suction

Sources & evidence

ORD record
ord-33c0a24bbc004e02b41f2dbec3dfa8f8
Source dataset
uspto-grants-2009_12
Patent number
US07626021B2

Reaction notes

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