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HRID1865783

反应详情

EQUATION

反应方程式

HRID 1865783 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1
HCID161915

Tosylmethyl isocyanide

C9H9NO2S

结构：CC1(O)C(O)C(CO)OC1n1cc(C=O)c2c(Cl)ncnc21
HCID21040838

未命名化合物

PRODUCTS

生成物

1
结构：CC1(O)C(O)C(CO)OC1n1cc(-c2cnco2)c2c(Cl)ncnc21
HCID86623589

未命名化合物

PROCEDURE

实验过程

To the compound from Step 1 is added tosylmethyl isocyanide (1 eq.) in MeoH containing K2CO3 (1 eq.) and the mixture is heated to reflux until starting material is consumed. The solvent is removed in vacuo and the crude mixture purified by RP HPLC on a Phenominex column (250×20 mm) using a gradient of acetonitrile in water from 0 to 30% over 30 minutes at 10 mL/minute.

WORKUP

后处理

  1. temperaturethe mixture is heated
  2. temperatureto reflux
  3. customis consumed
  4. customThe solvent is removed in vacuo
  5. customthe crude mixture purified by RP HPLC on a Phenominex column (250×20 mm)
  6. customover 30 minutes