3H-spiro(isobenzofuran-1,4'-piperidin)-3-one → 1'-[(1-Benzyl-2-methyl-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

HRID 1865938Notes

Reaction equation

HRID 1865938 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[O:7]2)[CH2:3][CH2:2]1.[CH2:16]([N:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]([C:32](O)=[O:33])=[C:24]1[CH3:35])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([N:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]([C:32]([N:1]2[CH2:6][CH2:5][C:4]3([C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=4[C:8](=[O:15])[O:7]3)[CH2:3][CH2:2]2)=[O:33])=[C:24]1[CH3:35])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 98342553H-spiro(isobenzofuran-1,4'-piperidin)-3-oneHCID 667434811-Benzyl-2-methyl-1H-indole-3-carboxylic acid

Product 1

HCID 159527101'-[(1-Benzyl-2-methyl-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Procedure

Following the general procedure I as described above, the acylation of 3H-spiro[2-benzofuran-1,4′-piperidin]-3-one prepared as described in example 16 above with 1-benzyl-2-methyl-1H-indole-3-carboxylic acid (preparation described in example 1), gave the title compound. ES-MS m/e (%): 451.6 (M+H+).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-fabc7af53dd0426c855b3302433ae64c
Source dataset
uspto-grants-2009_12
Patent number
US07629353B2

Reaction notes

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