Water → Ethyl 5-cyclopropyl-2-methyl-1,3-oxazole-4-carboxylate

HRID 1865988Notes

Reaction equation

HRID 1865988 reaction equation
C(OC(=O)[C:5]([NH:16][C:17](=[O:19])[CH3:18])([C:11]([CH:13]1[CH2:15][CH2:14]1)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.O>CS(C)=O>[CH2:9]([O:8][C:6]([C:5]1[N:16]=[C:17]([CH3:18])[O:19][C:11]=1[CH:13]1[CH2:14][CH2:15]1)=[O:7])[CH3:10]

Participants

4

Reactant 2

HCID 962WaterHCID 69016854HCID 69016854, compound

Product 1

HCID 59657553Ethyl 5-cyclopropyl-2-methyl-1,3-oxazole-4-carboxylateYield 34%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2-Acetylamino-2-cyclopropanecarbonyl-malonic acid diethyl ester in DMSO was treated with 2 eq H2O and stirred at room temperature for 6 h then extracted with Et2O to give after concentration the title compound in 34% yield.

Workup

  1. extractionthen extracted with Et2O
  2. customto give
  3. concentrationafter concentration the title compound in 34% yield

Sources & evidence

ORD record
ord-2634cb90a09343fe911408851a0b30d4
Source dataset
uspto-grants-2009_12
Patent number
US07629353B2

Reaction notes

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