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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1865988Generated: November 4, 2026

Water → Ethyl 5-cyclopropyl-2-methyl-1,3-oxazole-4-carboxylate

https://huagongshe.com/reaction/1865988

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantHCID 69016854HCID 69016854—
SolventDimethyl SulfoxideHCID 679—
ProductEthyl 5-cyclopropyl-2-methyl-1,3-oxazole-4-carboxylateHCID 5965755334%

Reaction Steps

2-Acetylamino-2-cyclopropanecarbonyl-malonic acid diethyl ester in DMSO was treated with 2 eq H2O and stirred at room temperature for 6 h then extracted with Et2O to give after concentration the title compound in 34% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07629353B2
Source datasetuspto-grants-2009_12
ORD IDord-2634cb90a09343fe911408851a0b30d4
Source noteuspto-grants-2009_12