反应详情

Using General Procedure G: 6-methoxy-2-tetralone (112 mg, 0.63 mmol), N-(2-nitrobenzenesulfonyl)-N-(2-pyridinylmethyl)-1,4-benzenedimethanamine (186 mg, 0.45 mmol) and NaBH3CN (110 mg, 1.76 mmol) in a mixture of MeOH (5 mL), trimethyl orthoformate (2.8 mL) and acetic acid (5 drops) were reacted for 3.5 hours. Purification of the crude material by chromatography on silica gel (CH2Cl2/MeOH/NH4OH 98:1:1) gave the desired product (102 mg, 40%) as a yellow foam.

1. customwere reacted for 3.5 hours
2. customPurification of the crude material by chromatography on silica gel (CH2Cl2/MeOH/NH4OH 98:1:1)